Adaptimmune Therapeutics plc
Adaptimmune is a leader in TCR T-cell therapy, focused on developing novel cancer immunotherapy products. We utilize the body’s own machinery – the T-cell – to target and destroy cancer cells by increasing the affinity of naturally occurring T-cell receptors (TCRs). We have developed a proprietary T-cell receptor platform that enables us to identify cancer targets, find and genetically engineer T-cell receptors, or TCRs, and produce TCR therapeutic candidates called SPEAR (Specific Peptide Enhanced Affinity Receptor) T-cells that recognize these targets on cancer cells. We engineer a patient’s own T-cells to express our SPEAR TCRs to target and potentially destroy tumors.
Nasdaq: ADAP
IR Website: https://www.adaptimmune.com/investors-and-media
Headquarters: United Kingdom
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Summary
Adaptimmune is a leader in TCR T-cell therapy, focused on developing novel cancer immunotherapy products. We utilize the body’s own machinery – the T-cell – to target and destroy cancer cells by increasing the affinity of naturally occurring T-cell receptors (TCRs). We have developed a proprietary T-cell receptor platform that enables us to identify cancer targets, find and genetically engineer T-cell receptors, or TCRs, and produce TCR therapeutic candidates called SPEAR (Specific Peptide Enhanced Affinity Receptor) T-cells that recognize these targets on cancer cells. We engineer a patient’s own T-cells to express our SPEAR TCRs to target and potentially destroy tumors.
Our wholly-owned pipeline includes SPEAR T-cell therapies targeting ADP-A2M10 (MAGE-A10), ADP-A2M4 (MAGE-A4), and ADP-A2AFP (AFP), which are being investigated in clinical studies across multiple solid tumor indications. We continue to build a pipeline of further proprietary TCR therapeutic candidates, next-generation treatment options, as well as allogeneic (off-the-shelf) solutions.
Investor Presentation
Recent News
Adaptimmune Announces Appointment of Cintia Piccina as Chief Commercial Officer
Jan 26, 2022
Translational Data at SITC 2021 from Adaptimmune’s Phase 1 SURPASS Trial Indicate Adding AKTi to Manufacturing May Contribute to Sustained Antitumor Activity of Next-gen SPEAR T-cells
Nov 12, 2021
Adaptimmune Reports Positive Results from its Pivotal SPEARHEAD-1 Trial in Patients with Synovial Sarcoma and MRCLS at CTOS
Nov 11, 2021
Adaptimmune Reports Third Quarter Financial Results and Business Update
Nov 4, 2021
Management Overview
Adrian (Ad) Rawcliffe
Chief Executive Officer
Adrian (Ad) Rawcliffe has served as our Chief Executive Officer since September 2019 and is a member of our Executive Team. Previously, he served as our Chief Financial Officer from March 2015 through September 2019.
Mr. Rawcliffe has over 20 years of experience within the biopharmaceutical industry and most recently served as Senior Vice President, Finance of GSK’s North American Pharmaceuticals business. He joined GSK in 1998 and his other senior roles at the company included Senior Vice President Worldwide Business Development and R&D Finance, where he was responsible for all business development and finance activities for GSK’s Pharmaceuticals R&D business and Managing Partner and President of SR One Ltd, GSK’s venture‑capital business. Mr. Rawcliffe currently serves as a non‑executive director of WAVE Life Sciences (NASDAQ: WVE).
Mr. Rawcliffe qualified as a chartered accountant with PwC and holds a B.Sc. degree in Natural Sciences from the University of Durham, UK.
William (Bill) Bertrand
Chief Operating Officer
William (Bill) Bertrand has served as our Chief Operating Officer since March 2017 and is responsible for operational functions including compliance, risk management, human resources, quality and legal/IP, as well as investor relations, communications and IT and facilities. He is a member of our Executive Team.
Mr. Bertrand’s prior experience includes a 12 year tenure at MedImmune, where he served as its first General Counsel and Chief Compliance Officer, along with holding a variety of operational and corporate strategy roles. He has also formerly served as Executive Vice President, General Counsel for Infinity Pharmaceuticals, Inc., and as Senior Vice President, Acting Chief Operating Officer and General Counsel for Salix Pharmaceuticals, where he remained as General Manager to help finalize the integration of the company’s $14 billion acquisition by Valeant Pharmaceuticals in April 2015. He is currently a member of the board of directors of Ardelyx, Inc. (NASDAQ: ARDX) and has served as a member of the board of directors of several private companies including Trustwave and Inotek Pharmaceuticals. Mr. Bertrand received a J.D. from the University of Wisconsin and a B.S. in biology from Wayne State University.
Joanna (Jo) Brewer, Ph.D.
Senior Vice President, Allogeneic Research
Dr. Jo Brewer has served as Senior Vice President, Allogeneic Research since December 2019. She leads our efforts to generate new, off-the-shelf, cell therapies for people with cancer, as well as our work to develop the manufacturing processes for these therapies. Dr. Brewer has led our Allogeneic Research team since 2018.
Dr. Brewer has more than 18 years of experience in immunotherapy research, specifically preclinical development from the early research phase towards first-in-human trials. Dr. Brewer was one of the founding scientists at Adaptimmune in 2008, working on the early SPEAR T-cell programs such as NY-ESO (now transitioned to GSK) and ADP-A2AFP. She built multiple research teams over 11 years aimed at improving the efficacy of SPEAR T-cell therapies through translational learning leading to the development of multiple next-gen approaches the first of which, ADP-A2M4CD8, is being tested in the SURPASS trial.
Dr. Brewer worked as a Senior Scientist at Avidex (the predecessor company to Adaptimmune), between 2001 and 2006, working on the autoimmune disease programs. She remained at Medigene as a Group Leader, following its acquisition of Avidex, until 2008.
Dr. Brewer holds a master’s degree in Natural Sciences and a Ph.D. in Cellular Signalling from the University of Cambridge.
John Lunger
Chief Patient Supply Officer
John Lunger has served as our Chief Patient Supply Officer since August 2019 and is a member of our Executive Team. John leads the teams responsible for producing and delivering products to patients, accelerating supply execution, and optimizing the supply chain to be ready for commercialization. Prior to joining our Executive Team, he was Senior Vice President, Manufacturing and Supply Chain at Adaptimmune, having joined the Company in March of 2017. In this role, he was responsible for clinical manufacturing and global supply of Adaptimmune’s autologous T-cell therapy products.
Previously, John was Head of Supply Chain and Commercial Product Supply at Merrimack Pharmaceuticals where he led clinical and commercial supply chain as well as the cross functional supply team for Merrimack’s first commercial product launched in October of 2015. Earlier in his career, he held various senior manufacturing, operational, and strategy roles with VWR International, Pfizer, and Wyeth Pharmaceuticals. In his nearly 10 years with Wyeth he held a number of leadership positions, including operations and supply chain strategy, supply management, procurement and strategic sourcing, business systems implementation, generic pharmaceutical business management, and site operations management in a pharmaceutical manufacturing plant in Ireland. John began his career serving as a nuclear trained officer on a U.S. Navy submarine followed by strategic consulting with Accenture.
John holds a Bachelor of Science degree (with distinction) in Ocean Engineering from the US Naval Academy and an MBA in economics and operations management from the University of Chicago’s Booth School of Business.
Karen Miller, Ph.D.
Senior Vice President, Pipeline Research
Dr. Karen Miller has served as Senior Vice President of our Pipeline Research team since April 2019, working to design, engineer and validate advanced cell therapies for the treatment of cancer.
Dr. Miller is an immunologist by training with more than 25 years of experience in drug discovery across a range of therapeutic areas including oncology, inflammatory disease, and neurosciences. She has broad experience in small molecule and biological drug discovery with more recent experience in cell and gene therapy.
Dr. Miller joined Adaptimmune in 2019 from GSK where she was Vice President, Head of the Immunology Innovation Fund from 2017, with responsibility for sourcing and evaluating internal and external project opportunities in immunology across multiple therapeutic areas including oncology. From 2013 to 2017, she led GSK’s cytokine, chemokine, and complement discovery performance unit taking projects, such as otilimab and sirukumab, from target identification and validation through to late-stage clinical trials.
Her prior roles have included Head of Biology for UCB Pharma, from 2006 to 2013, making contributions to the development of brivaracetam, lacosamide, levetiracetam, rotigotine, and certolizumab pegol. Between 1998 and 2006, she was Head of Biology at Vertex.
She earned a B.Sc. degree in Medical Cell Biology and a Ph.D. in cell secretory mechanisms from Liverpool University and a PhD funded by a Biotechnology and Biological Sciences Research Council Co-operative Award in Science and Engineering award with ICI Pharmaceuticals before starting her research career at Imperial College in London.
Elliot Norry, M.D.
Chief Medical Officer
Elliot Norry has served as our Chief Medical Officer (CMO) since January 2020 after having served as our acting CMO since August 2019. He is a member of our Executive Team.
Previously, Dr. Norry was Vice President and Head of Clinical Safety and Pharmacovigilance at Adaptimmune, and leader of our ADP-A2AFP program, having joined the company in July 2015.
Prior to joining Adaptimmune, Dr. Norry served as Safety Development Leader at GSK from 2009, where he managed clinical safety for a broad range of early and late stage products, including approval activities for pazopanib for the treatment of soft tissue sarcoma. He was also Chair of GSK’s Hepatic Safety Panel.
Prior to his roles in the biotech and pharmaceutical industry, Dr. Norry practiced adult internal medicine at Abington Memorial Hospital in Abington, Pennsylvania for 13 years. He holds a B.A. from Columbia College and an M.D. from New York University. He performed his residency in Internal Medicine at Temple University Hospital in Philadelphia and his fellowship in gastroenterology at Thomas Jefferson University Hospital in Philadelphia.
Cintia Piccina
Chief Commercial Officer
Cintia Piccina has served as our Chief Commercial Officer since January 31, 2022 and is a member of our Executive Team.
Most recently, Cintia served as the Head of Commercial at 2Seventy Bio (Nasdaq:TSVT) and as SVP Commercial Oncology and US General Manager, leading the launch of the first cell therapy product in multiple myeloma, Abecma (idecabtagene vicleucel), for bluebird bio (Nasdaq:BLUE). Before that she spent over 20 years at Novartis (SIX:NOVN; NYSE:NVS) from 1997 to April 2020, first in Brazil then in the United States, where she held a series of commercial, marketing and sales roles across multiple therapeutic areas including oncology. In her final role at Novartis, Cintia was VP, Global Oncology Cell and Gene Strategy & Program Management Office, for Kymriah and the CAR-T pipeline, leading the cross-functional leadership teams for business (marketing, medical affairs, market access), manufacturing, and pipeline.
Cintia holds a Doctorate in Pharmacy and Biochemistry from the University of Sao Paulo, Brazil, and an M.B.A. from the Escola Superior de Propaganda e Marketing, Sao Paulo.
Helen Tayton-Martin, Ph.D., M.B.A.
Chief Business Officer
Dr. Helen Tayton-Martin has served as our Chief Business Officer since March 2017, having formerly served as our Chief Operating Officer since 2008, a role in which she oversaw the transition of all operations in the company from five to 300 staff, through transatlantic growth, multiple clinical, academic and commercial collaborations and private and public financing through to its Nasdaq IPO. She is a member of our Executive Team.
As our CBO, Dr. Tayton-Martin is responsible for optimizing the strategic and commercial opportunity for Adaptimmune’s assets, leading on business development and commercial activities. Her role encompasses all aspects of pipeline and technology assessment, strategic portfolio analysis, integrated program management and commercial planning and partnerships, including the company’s strategic partnership with GlaxoSmithKline (LSE/NYSE: GSK).
Dr. Tayton‑Martin has over 26 years of experience working within the pharma, biotech and consulting environment in disciplines across preclinical and clinical development, outsourcing, strategic planning, due diligence and business development. She co‑founded Adaptimmune from the former company, Avidex Limited, where she had been responsible for commercial development of the soluble TCR program in cancer and HIV from 2005 to 2008.
Dr. Tayton‑Martin previously served as a non‑executive director of Trillium Therapeutics Inc. (Nasdaq and TSX: TRIL) from October 2017 through the sale of the company in November 2021. She holds a Ph.D. in molecular immunology from the University of Bristol, U.K. and an M.B.A. from London Business School.
Dennis Williams, Pharm.D.
Senior Vice President, Late Stage Development
Dennis Williams has served as Senior Vice President, Late Stage Development since December 2019 and is responsible for overseeing our late stage pipeline activities, including Phase 2/3 clinical trials through market application submission and approval.
Dr. Williams joined Adaptimmune in 2015 and served as Vice President, Global Regulatory Affairs. He has also led our ADP-A2M4 development program and previously led the NY-ESO development program prior to the transition of NY-ESO to GSK.
Prior to joining Adaptimmune, Dr. Williams served as Director and Global Regulatory Lead at GSK Oncology, where he was instrumental in the development and approval of innovative products such as PROMACTA®/REVOLADE®.
Dr. Williams has 20 years of experience in the pharmaceutical and biotech industries and started his career in the pharmaceutical industry in 2000 at Teva Pharmaceuticals. Dr. Williams holds a Doctorate in Pharmacy (Pharm.D.) from the University of Florida and a Bachelor of Science degree in Pharmacy from Temple University.
Gavin Wood
Chief Financial Officer
Gavin Wood has served as our Chief Financial Officer since April 2020 and is a member of our Executive Team.
Mr. Wood has held CFO and senior management roles in public companies in the life sciences sector since 2006. Most recently, he served as the Chief Financial Officer and a director of Abcam plc (LSE: ABC) from September 2016 through February 3, 2020, working as part of the executive team that led the company through a period of significant growth and change. Before that, he held a series of roles at Affymetrix Inc, (NASDAQ: AFFX) from 2006 to 2016, including serving as Executive Vice President and Chief Financial Officer from May 2013 through March 2016, and managing the global finance, IT, internal audit and facilities functions, until the company was acquired by ThermoFisher Scientific.
Mr. Wood is a Chartered Accountant and holds a B.A. degree in Archaeology from the University of Durham, UK.
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