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aTyr Pharma
aTyr Pharma (NASDAQ: LIFE) is a clinical stage biotechnology company whose mission is to translate their proprietary tRNA synthetase biology platform into a new class of medicines to treat life-threatening forms of cancer, fibrosis and inflammation.
Nasdaq: LIFE
IR Website: https://investors.atyrpharma.com/news-releases
Headquarters: San Diego, California
Content provided by aTyr Pharma on 2-10-22.
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Summary
aTyr Pharma (NASDAQ: LIFE) is a clinical stage biotechnology company whose mission is to translate their proprietary tRNA synthetase biology platform into a new class of medicines to treat life-threatening forms of cancer, fibrosis and inflammation.
aTyr’s lead clinical product candidate, efzofitimod (ATYR1923), is a potential first-in-class, selective modulator of neuropilin-2 (NRP2) that downregulates innate and adaptive immune responses in inflammatory disease states. Efzofitimod is in clinical development for its pulmonary sarcoidosis, a major form of interstitial lung disease (ILD), a group of immune-mediated lung disorders that can result in lung fibrosis. The company recently established clinical proof-of-concept for efzofitimod in a Phase 1b/2a multi-center, randomized, placebo-controlled clinical trial in pulmonary sarcoidosis. Efzofitimod has received U.S. FDA orphan drug designation for sarcoidosis and the company expects to initiate a registrational study in pulmonary sarcoidosis in 2022. The company has a partnership with Kyorin Pharmaceutical for the development and commercialization of efzofitimod for ILD in Japan.
aTyr is also advancing a pre-clinical pipeline of NRP2-targeting antibodies. This includes lead IND candidate ATYR2810, which is expected to enter a Phase 1 study in cancer in 2022. The company is also exploring other tRNA synthetases, which may have therapeutic applications in cancer and inflammation.
aTyr owns a global intellectual property estate directed to all 20 human tRNA synthetases and some associated signaling pathways, with over 300 protein compositions patented.
Investor Presentation
Recent News
ATYR PHARMA TO PARTICIPATE IN PANEL AT NATIONAL INSTITUTES OF HEALTH RARE DISEASE DAY®
Feb 23, 2022
ATYR PHARMA TO PRESENT AT BIO CEO & INVESTOR CONFERENCE
Feb 7, 2022
ATYR PHARMA ADVANCES DEVELOPMENT OF LEAD THERAPEUTIC CANDIDATE ATYR1923 WITH ANNOUNCEMENT OF “EFZOFITIMOD” AS NONPROPRIETARY NAME
Jan 13, 2022
ATYR PHARMA ANNOUNCES FDA ORPHAN DRUG DESIGNATION FOR ATYR1923 FOR TREATMENT OF SARCOIDOSIS
Jan 6, 2022
ATYR PHARMA TO PRESENT AT H.C. WAINWRIGHT VIRTUAL BIOCONNECT CONFERENCE
Jan 4, 2022
Management Overview
Sanjay S. Shukla, M.D., M.S.
Chief Executive Officer, President and Director
Sanjay S. Shukla, M.D., M.S. has served as our President and Chief Executive Officer and as a board member since November 2017. Dr. Shukla served as our Chief Medical Officer from March 2016 to November 2017. From April 2015 to March 2016, Dr. Shukla worked in an advisory capacity for a number of companies, including as a consultant to aTyr from January 2016 to March 2016. Prior to that, from October 2012 to April 2015, Dr. Shukla served as Vice President and Global Head of Integrated Medical Services for Novartis, a biopharmaceutical company, where he led global medical affairs operations, with oversight for all pharma general medicines therapies, both inline and in development. Dr. Shukla served as Chief Executive Officer of RXMD, a clinical development consultancy that assisted in advancing proof of concept for early stage drug candidates, from April 2009 to September 2012. Prior to that, Dr. Shukla served in a variety of clinical development, data analytics and drug safety roles at Vifor Pharma, a biopharmaceutical company, and Aspreva Pharmaceuticals (acquired by Vifor Pharma). Dr. Shukla received his M.D. from Howard University College of Medicine and his Bachelors of Science in Microbiology and Master of Science in Epidemiology and Biostatistics from the University of Maryland.
Jill Broadfoot
Chief Financial Officer
Jill Broadfoot has served as our Chief Financial Officer since July 2018. Prior to joining aTyr, from January 2017 to July 2018, Ms. Broadfoot served as Chief Financial Officer of Emerald Health Pharmaceuticals Inc. and Emerald Health Bioceuticals Inc. where she was responsible for establishing operations for the U.S.-based pharmaceutical and bioceuticals entities as well as the establishment of operations, corporate governance, finance and accounting and investor relations functions, among others. Prior to Emerald Health, Ms. Broadfoot served as Vice President, U.S. Corporate Controller at GW Pharmaceuticals, from May 2016 to January 2017. While at GW Pharmaceuticals, her responsibilities included establishing U.S. commercial operations and implementing U.S. public company financial and accounting standards in connection with the transfer of corporate operations from the U.K. to the U.S. Prior to joining GW Pharmaceuticals, Ms. Broadfoot served as Chief Financial Officer of Vical Inc., from October 2004 to March 2013, where she had oversight of finance, investor relations, manufacturing, information technology, human resources, and business development. Before joining Vical, Ms. Broadfoot held various positions at DJO Global, Inc., most recently as Vice President of Finance. Ms. Broadfoot also served as an audit manager at Ernst & Young LLP. She currently serves on the board of directors for Otonomy, Inc. and AcelRx Pharmaceuticals, Inc. Ms. Broadfoot holds a B.S. in business administration and accounting from San Diego State University and is a Certified Public Accountant.
Nancy Denyes
General Counsel
Nancy Denyes has served as our General Counsel since February 2019 and as our Corporate Secretary since January 2015. Ms. Denyes served as our Vice President, Legal Affairs from October 2014 to February 2019. And provided consulting services to us from 2013 to 2014. Ms. Denyes practiced law in the corporate department at Cooley LLP and was named partner in 2000. Her practice at Cooley was focused on securities and corporate matters, including private financings, public offerings, mergers and acquisitions and corporate governance and disclosure issues. Ms. Denyes holds a J.D. from University of California, Berkeley School of Law and B.A. in Economics and Business from the University of California, Los Angeles.
Andrea Cubitt, Ph.D.
VP, EXTERNAL SCIENTIFIC ALLIANCES & INTELLECTUAL PROPERTY
Andrea Cubitt, Ph.D. has served as our Vice President, External Scientific Alliances and Intellectual Property since February 2018 and served as our Vice President, Product Protection from September 2011 to February 2018. Dr. Cubitt worked as a consultant for us from January 2011 to September 2011. Prior to that, from 2009 to 2011, she worked as a senior patent agent for the Global Patent Group LLC, a patent consulting firm. She co-founded Anaptys Biosciences, a therapeutic antibody company, in 2005 and served as Executive Director of Corporate Development until 2009. She also served as Senior Manager, Technology and Intellectual Property at Aurora Bioscience Corporation, a biotechnology company. Dr. Cubitt did her postdoctoral training at Weill Cornell Medical College in New York, and at the University of California San Diego, where she was part of team that initiated development of the green fluorescent protein (“GFP”) with Roger Tsien, Ph.D. Dr. Cubitt holds a Ph.D. in biochemistry from the University of Sheffield and a first class honors degree (B.Sc) in medical biochemistry from the University of Birmingham in the UK. Dr. Cubitt is a co-inventor or co-author of 18 issued US patents and 20 publications.
Leslie Nangle, Ph.D.
VP, Research
Leslie Nangle, Ph.D., has served as our Vice President, Research since January 2021. Dr. Nangle has served in scientific research roles at aTyr since joining the company in 2007, including most recently as Sr. Director and Head of Research. Dr. Nangle has over 20 years of experience in research dedicated to extracellular tRNA synthetases. Throughout her tenure at aTyr, she has co-developed and implemented the company’s discovery platform to generate an intellectual property estate of over 300 potential therapeutically relevant proteins and has overseen research leading to the discovery of a splice variant of histidyl-tRNA synthetase that has been shown to modulate the immune system, providing the basis of aTyr’s lead program, ATYR1923. Prior to joining aTyr, Dr. Nangle received a Ph.D. in Macromolecular Cellular Structure and Chemistry from The Scripps Research Institute in La Jolla, CA, studying the emerging linkage between mutations in tRNA synthetases and inherited neuropathies under the mentorship of Dr. Paul Schimmel, who co-founded aTyr in 2005. Dr. Nangle received a bachelor of science in biology from the University of California at Santa Barbara. She is co-author or co-inventor of over 75 publications and issued or pending U.S. patents.
Robert W. Ashworth, Ph.D.
VP, Regulatory Affairs
Robert W. Ashworth, Ph.D. has served as our Vice President, Regulatory Affairs since October 2021. Prior to joining aTyr, from July 2018 to September 2021, Dr. Ashworth was Vice President, Regulatory Affairs, Quality and CMC at OncoSec Medical, Inc., where he developed and executed the regulatory strategy for novel immunotherapy products for cancer. From 2015 to 2018, he was Vice President, Regulatory Affairs, Quality and Compliance for Advaxis, Inc., where he developed and executed the global regulatory strategy for the company’s immunotherapy platform. Prior to that, he was Vice President, Global Regulatory Affairs at NPS Pharmaceuticals. There he was instrumental in negotiating the approval of NATPARA (PTH) for hypoparathyroidism. When he was Vice President, Regulatory Affairs at Otsuka Pharmaceutical Development, Inc., he executed the regulatory strategy for ABILIFY®, the company’s flagship product. He has also held positions with Biovail Corporation, Forest Laboratories, Inc., and Knoll Pharmaceuticals Company, among other companies. Dr. Ashworth earned a B.S. in Chemistry from St. John’s University and a Ph.D. in Organic Chemistry from the Massachusetts Institute of Technology.
Danielle Campbell
VP, Human Resources
Danielle Campbell has served as our Vice President, Human Resources since December 2021. Prior to joining aTyr, Ms. Campbell worked at Poseida Therapeutics, Inc., from 2016-2018 in roles related to human resources and facilities management. From 2019-2021, she was Senior Director, Facilities Operations, where she directed all facility operations including site development, maintenance, planning and environmental health and safety. From 2016-2018, she held roles in human resources at Poseida, including Director, Human Resources from 2018-2019 and Senior Manager, Human Resources from 2016-2018, where she managed daily human resources functions to support rapid growth, development and retention of team members. Prior to joining Poseida, Ms. Campbell was Human Resources Manager for aTyr Pharma, Inc., from 2015-2016, where she managed and supported daily human resources functions. Ms. Campbell began her career in human resources with earlier positions including Manager, Human Resources for Celladon Corporation from 2014-2015 and Manager, Human Resources & Equity Plans for Cytori Therapeutics, Inc. Ms. Campbell received a B.A. in Criminology, Law and Society from the University of California, Irvine School of Social Ecology.
Risks & Disclosures
This communication is neither an offer to sell nor a solicitation of an offer to buy, nor a recommendation of any securities of the company mentioned herein.
aTyr Pharma (the “Company”) and its counsel have reviewed the content of this page as well as the accompanying presentation (“Company Presentation”) displayed on this page. To the best of its knowledge, the Company does not believe this content to be misleading or inaccurate in any material respect, nor does it believe there are any material omissions with respect to such content. The Company does not believe the contents of the page or the Company Presentation to contain any non-public material information.
Information and opinions presented in the Company Presentation are provided by the Company, and b2i digital makes no representation as to their accuracy or completeness. The information contained on this page is not intended to constitute any form of advice, and the information provided is not intended to provide a sufficient basis on which to make an investment decision. It is not investment research, nor does it constitute a research recommendation, as it does not constitute substantive research or analysis. This information is not to be relied upon in substitution for the exercise of independent judgment.
Information, opinions and estimates contained on this page or in the Company Presentation reflect judgments by the Company as of the original date of publication by the Company and are subject to change without notice. Past performance should not be taken as an indication or guarantee of future performance, and no representation or warranty, express or implied is made regarding future performance.
A complete description of the risks and uncertainties relating to the Company and its securities can be found in the company's filings with the U.S. Securities and Exchange Commission available for free at www.sec.gov.
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